The 49ers open the season on the road against the Dallas Cowboys on Sept. 7, their first regular-season game in Dallas since 2008.
The debut of Levi’s Stadium is hardly the only high-profile game on the 2014 slate, as the 49ers have three other prime-time games and are part of Saturday doubleheader in Week 16.
The juiciest matchup on the schedule is a Thanksgiving night showdown on Nov. 27 against the defending Super Bowl champion Seattle Seahawks, who beat the 49ers in the NFC Championship Game.
The 49ers play the Seahawks two out of three weeks, heading up to Seattle on Dec. 14. A trip across the Bay to take on the Raiders on Dec. 7 is sandwiched in between. It will be the first time the 49ers have played in Oakland since 2002.
Other prime-time games are a Monday night NFC West clash against the Rams in St. Louis on Oct. 13 and a Sunday night road game Oct. 19 against the Denver Broncos. Those two road games are part of a stretch in which the 49ers will play four out of five games away from Santa Clara.
On Dec. 20, the 49ers will be part of a Saturday doubleheader hosting the San Diego Chargers before Philadelphia and Washington play later in the day.
The NFL season kicks off Sept. 4 with the Green Bay Packers traveling to Seattle to take on the Seahawks.
Sept. 7 at Dallas, 1:25 p.m.
Sept. 14 vs. Chicago, 5:30 p.m.
Sept. 21 at Arizona, 1:05 p.m.
Sept. 28 vs. Philadelphia, 1:25 p.m.
Oct. 5 vs. Kansas City, 1:25 p.m.
Oct. 13 at St. Louis, 5:30 p.m.
Oct. 19 at Denver, 5:30 p.m.
Oct. 26 Bye week
Nov. 2 vs. Rams, 1:05 p.m.
Nov. 9 at New Orleans, 10 a.m.
Nov. 16 at N.Y. Giants, 10 a.m.
Nov. 23 vs. Washington, 1:25 p.m.
Nov. 27 vs. Seattle, 5:30 p.m.
Dec. 7 at Raiders, 1:25 p.m.
Dec. 14 at Seattle, 1:25 p.m.
Dec. 20 vs. San Diego, 1:30 p.m.
Dec. 28 vs. Arizona, 1:25 p.m.