Jill Reese, 72, had been reported missing Tuesday after she failed to show up for an appointment in Orinda and didn't come back home, Piedmont police said.
She had last been seen Tuesday around 11 a.m. at her Piedmont home.
Piedmont police had said Wednesday that she had been "located," but did not provide additional information.
San Francisco police Officer Gordon Shyy said Piedmont police asked San Francisco police to respond to a hotel in the 700 block of Market Street. Officers found Reese deceased in a hotel room at about 10 a.m. Wednesday.
The Four Seasons Hotel is located at 757 Market St.
Shyy said her death does not appear to be suspicious.
Piedmont police declined to provide more information about the case.