CHP officers spotted a BMW stolen out of San Francisco on northbound Interstate Highway 880 near Seventh Street in Oakland around 3 a.m., CHP Officer Sean Wilkenfeld said.
The driver of the BMW led officers on a chase from Oakland at speeds of around 50 mph to westbound I-80, he said.
The BMW then continued traveling on the Bay Bridge and accelerated to speeds of more than 100 mph once on the bridge, Wilkenfeld said.
The BMW driver exited at the Fifth Street off-ramp in San Francisco, where the driver crashed into the left wall of the ramp and the car caught on fire, he said.
A man was ejected from the car and killed, while the other occupant was killed inside the car, according to Wilkenfeld.
The two people in the car have yet to be identified, according to the San Francisco medical examiner's office.
A Sig-alert was issued at 3:19 a.m. and the off-ramp was closed until just before 9:30 a.m., Wilkenfeld said.
Motorists were detoured to alternate exits during the nearly six-hour closure, he said.