Gordon Beckham hit an RBI single with two outs in the 10th inning and the Chicago White Sox beat the Giants 3-2 on Tuesday at AT&T Park after blowing a two-run lead in the ninth.
One batter after Jordan Danks was thrown out trying to score from third on a fielder's choice, Beckham hit an 0-1 pitch from Santiago Casilla (1-2) past shortstop Brandon Crawford into left field. Sierra, who entered the game as a late defensive replacement, scored easily.
Adam Dunn hit a two-run home run off Giants starter Ryan Vogelsong in the first for Chicago, which wasted another strong start by Chris Sale when reliever Jake Petricka gave up four hits in the ninth.
Beckham, who made two stellar defensive plays including one in the ninth, bailed out the White Sox bullpen with only hit in five at-bats.
Zach Putnam (4-2) pitched 1 1-3 innings for the win.
Sale struck out 12 and walked two over eight solid innings in his best start of the season. It's the 16th time in 77 career starts that Sale has fanned 10 or more -- second-most in franchise history -- and a team-record ninth time with 12 or more.
It's also the fourth time this season the All-Star pitcher left with a lead only to have the Chicago bullpen let it slip away.
Pablo Sandoval, Mike Morse and pinch-hitter Travis Ishikawa singled to load the base with no outs in the ninth. Joe Panik grounded into a 4-6-3 double play to score Sandoval before Crawford's two-out single tied it.
Vogelsong struck out five and walked two in six innings. He allowed only one hit following Dunn's home run -- a leadoff triple by Conor Gillaspie in the second -- then retired the next seven.
It wasn't enough to keep San Francisco from falling a season-high six games behind the Dodgers in the AL West. The Giants led the division by 9 1/2 games on June 8 but have gone just 20-36 since.
White Sox: RHP Matt Lindstrom was reinstated from the disabled list for the first time since undergoing surgery on May 23 to repair a torn sheath in his left foot. Lindstrom (2-1, six saves) pitched in five games on his rehab assignment. He takes the roster spot of LHP Eric Surkamp, who was optioned to Triple-A Charlotte on Sunday.
Giants: RHP Matt Cain underwent season-ending surgery to remove bone chips in his pitching elbow. Recovery is expected to take three months of rehabilitation. ... C Hector Sanchez (concussion) has resumed his rehab with Triple-A Fresno.
White Sox: LHP Jose Quintana (6-8), who has one loss over his previous 10 starts, makes his first career appearance against San Francisco in the final half of this brief two-game series.
Giants: RHP Jake Peavey, winless in three starts with the Giants, allowed one run over six innings against Chicago on April 15 when he was still with Boston.