After two losses to the Los Angeles Dodgers in Australia, they truly open at home Monday against the Giants.
Left-hander Madison Bumgarner, an All-Star last season, makes his first Opening Day start for the Giants and Brandon McCarthy starts for the Diamondbacks.
The four-game series features two teams that will try to unseat the favored Dodgers in the NL West.
San Francisco won the division title and the World Series two years ago, a year after the Diamondbacks finished atop the NL West.
Arizona has been hit by significant injuries to its top starting pitcher, Patrick Corbin, and its bullpen setup man, David Hernandez.
“Virtually every team is going to have obstacles,” Diamondbacks manager Kirk Gibson said. “We’ve had some hit us early. We”ll be resilient. We’ll have to fight through it.”
Bumgarner, at 24 the youngest of the San Francisco starters, was 13-9 with a 2.77 ERA in 31 starts last season. As usual, starting pitching is the Giants’ strength, with a rotation that includes Matt Cain, Tim Lincecum and 38-year-old newcomer Tim Hudson.
The Giants finished third in the NL West last season, behind the Dodgers and Diamondbacks.
“There’s a bad taste in everybody’s mouths,” San Francisco catcher Buster Posey said.
San Francisco had a hard time scoring last year.
“We’ve got to pick it up here,” Giants manager Bruce Bochy said. “This is going to be a big road trip for us. We’ve got to have these bats going.”
Wade Miley and Trevor Cahill started in Australia for Arizona. Miley and Cahill will start the second and third games of the series against the Giants, while newcomer Bronson Arroyo, sidelined by a sore back during much of spring training, is to start the series finale.
The Giants will go with Cain, Hudson and Lincecum after Bumgarner.
McCarthy struggled with injuries last season, going 5-11 with a 4.53 ERA, but had a strong exhibition season It’s his second start in a home opener.
“It’s a cool opportunity,’” he said. “It’s always a first chance for the fans to get out and see the guys again. There’s always a lot of atmosphere there. It’s the closest you get to a playoff atmosphere in the regular season until the season starts drawing to an end. It’s a fun challenge.”
Arizona will open with rookie Chris Owings at shortstop. The Pacific Coast League player of the year last season beat out Didi Gregorius, who was optioned to Triple-A Reno.
Arizona, led by NL home run and RBIs leader Paul Goldschmidt, finished 81-81 for the second year in a row in a season slowed by injuries.
“We’ve already had two games under our belt, but the Giants are always a very good ballclub and play us tough,” Diamondbacks general manager Kevin Towers said. “Hopefully the adrenalin will be flowing and McCarthy will have his A-game going.”
Bochy doesn’t expect the Diamondbacks to have any hangover from their Sydney sojourn.
“They’ve had time to recuperate and recover,” Bochy said. “That’s what they made sure of when they made they made this trip that they could come back.”