A driver in a black Mercedes-Benz convertible rammed into Cliff's Variety store at 479 Castro St. around 5 a.m., according to police.
Police said the driver ran from the car and remains at large.
The storefront and children's section of the craft, tool, art and general supply store were damaged in the crash, according to store general manager Terry Asten Bennett.
Asten Bennett said several windows were broken, the entryway was crushed and an interior wall was pushed back.
She said the toy counter was also hit and the toy aisles have been cleared and are closed for repairs.
No one was at the store, which was scheduled to open at 9 a.m.
Instead, workers cleaned up debris from the crash and opened the doors closer to 10:30 a.m.
Asten Bennett said it was miraculous that no one was injured and that there weren't any transients sleeping in the doorway, which is a common occurrence.