Drew Brees passed for 265 yards and three touchdowns, and the New Orleans Saints led the New York Giants 21-3 at halftime on Monday night.
Two of Brees' scoring strikes went to Lance Moore, who had five catches for 54 yards.
Marques Colston had three catches for 78 yards, all on the Saints' 34-second, 88-yard touchdown drive late in the second quarter. Colston's longest reception went for 50 yards when he caught a pass along the left sideline, slipped a tackle and raced up field.
Tight end Jimmy Graham had four catches for 55 yards, including a 5-yard touchdown late in the second quarter.
The Saints struck first early in the second quarter on Brees' 4-yard touchdown pass to Moore, who snagged a quick pass on the right side and dove to stretch the ball across the goal line before he was tackled.
The 10-play, 80-yard scoring drive included a 23-yard pass to Graham and a 23-yard run by Darren Sproles.
All three Saints scoring drives went for 80 or more yards.
Giants quarterback Eli Manning had 171 yards passing in the first half, but was intercepted by Saints linebacker Will Herring in the end zone.
After that, the only scoring the Giants managed in the first half was Lawrence Tynes' 42-yard field goal. Tynes also attempted a 61-yarder, which fell short, at the end of the half.
The Giants, who have been struggling to run the ball all season and were without leading rusher Ahmad Bradshaw, gained only 29 yards on the ground in the opening two quarters.
Both teams missed scoring opportunities on their opening drives.
The Saints got close at the 18-yard line, but delay-of-game and offensive pass interference penalties moved them back before they attempted a fake field goal on fourth-and-11. Chase Daniel, the holder and backup quarterback, found Graham in the right flat, but Jason Pierre-Paul made an open-field tackle to stop Graham a yard short of a first down.
The Giants then marched to the Saints 18-yards line before Manning's pass intended for tight end Jake Ballard was intercepted by Herring.
Manning completed his first four passes for 64 yards, including a 26-yarder to Ramses Barden, before his interception.
Manning was looking for a strong performance in his return to his native New Orleans and the stadium where his father, Archie, starred for the Saints. This was a game the Giants were desperate to win after losing their previous two to San Francisco and Philadelphia.
If the Giants failed to come back, they would face the possibility of a four-game losing streak when they host the unbeaten Green Bay Packers next weekend.
The Saints, meanwhile, were looking to maintain a one-game lead over Atlanta in the NFC South.