Jozy Altidore will miss the U.S. men's soccer team's World Cup game against Portugal on Sunday because of his strained left hamstring and appears likely to sit out next week's match against Germany.
The U.S. probably needs to advance to the knockout phase if the forward is to return to the tournament.
Altidore was hurt in the 21st minute of Monday's 2-1 win over Ghana, and the U.S. Soccer Federation said Thursday he will not play against the Portuguese.
"He's a big player for us," midfielder Kyle Beckerman said. "We're extremely bummed for him and for the team, but we bring 23 players, and it's just a chance for somebody to step up. Hopefully the injury's not too bad and we can see Jozy later in the tournament."
Team spokesman Michael Kammarman did not reveal the severity of the strain. The Americans have just three days off between this weekend's game in Manaus and their first-round finale in Recife on June 26.
"It's bad news, but I think the team will handle this," midfielder Jermaine Jones said. "We have to handle that."
Aron Johannsson replaced Altidore for the second half against Ghana. Chris Wondolowski is the other striker who could join Clint Dempsey in the attack.
URUGUAY 2, ENGLAND 1
Luis Suarez scored twice to give Uruguay a 2-1 victory over England at the World Cup, making an instant impact on his return from injury to revive his team's Group D campaign.
The Liverpool striker, who hadn't played since undergoing surgery on his left knee last month, lashed in the winner in the 85th minute, after seeing his first-half opener canceled out by Wayne Rooney.
After surprisingly losing its Group D opener to Costa Rica, Uruguay's qualifying chances have now been given a major lift, while England's hopes of advancing to the round of 16 are in real jeopardy after its worst World Cup start in more than half a century.
Of Uruguay's six efforts on target, five were from Suarez -- including the two that beat goalkeeper Joe Hart as England's slack defending was exploited.
By taking his World Cup tally to five goals, Suarez ensured that Rooney's first goal in 10 matches on soccer's biggest stage was in vain at his third tournament.
COLOMBIA 2, IVORY COAST 1
Colombia qualified for the knockout stage, beating Ivory Coast after scoring twice in a six-minute spell in the second half.
Driven on by a partisan pro-Colombian crowd inside the Estadio Nacional, the South Americans went ahead through James Rodriguez's powerful header from a corner in the 64th minute before substitute Juan Quintero added a second on a break following a defensive error.
JAPAN 0, GREECE 0
Reduced to 10 men after captain Costas Katsouranis was sent off in the 38th minute with his second booking, Greece held on for a draw with Japan that kept both alive in Group C and sent rival Colombia through to the knockout round.